Author:
Wang Bin,Ye Ni,Cao San-jie,Wen Xin-tian,Huang Yongxs,Yan Qi-gui
Abstract
AbstractEnzootic nasal adenocarcinoma (ENA), an epithelial tumor induced in goats and sheep by enzootic nasal tumor virus (ENTV), is a chronic, progressive,contact transmitted disease. This study aimed to identify novel and differentially expressed miRNAs in the tumor and para-carcinoma nasal tissuesofNanjiang yellow goats with ENA. Small RNA Illumina high-throughput sequencing was used to construct a goat nasal miRNA library.406 known miRNAs and 29 novel miRNAs were identified. A total of 116 miRNAs were significantly differentially expressed in para-carcinoma nasal tissues and ENA; Target gene prediction and functional analysis revealed that 6176 non-redundancy target genes, 1792 significant GO and 97 significant KEGG pathway for 121 miRNAs were predicted.
Publisher
Cold Spring Harbor Laboratory
Reference56 articles.
1. Differential expression analysis for sequence count data
2. Growth stimulation of human breast cancer cells with anti-transforming growth factor beta antibodies: evidence for negative autocrine regulation bytransforming growth factor beta;Cell growth & differentiation: the molecular biology journal of the American Association for Cancer Research,1990
3. miR-122 – A key factor and therapeutic target in liver disease
4. MicroRNAs
5. MicroRNAs: Target Recognition and Regulatory Functions