A novel Wnt pathway orients Par complex-dependent cell polarity

Author:

Yoshiura Shigeki,Matsuzaki FumioORCID

Abstract

AbstractThe Par-complex is a highly conserved cell polarization machinery, playing critical roles in tissue development and homeostasis. However, how extracellular signals globally orient Par-dependent cell polarity in tissues remains poorly understood. We show here that four of seven Drosophila Wnts redundantly serve as directional cues for the Par-dependent cell polarity of neural stem cells, neuroblasts, through a novel pathway. Wnt2/5/6/D proteins, expressed in ectodermal cells, act via frizzled receptors on underlying neuroblasts to localize armadillo/β-catenin to neuroblast cytocortex facing the Wnt signal source. The localized armadillo recruits the Par complex and Pins complex to the neuroblast apical side, through the association of arm with Par3 and Inscuteable. Wnts consequently orient the cell polarity and asymmetric divisions of neuroblasts perpendicular to the epithelium, allowing nerve tissue to grow inward along the central-peripheral axis in Drosophila embryos. This novel non-canonical Wnt signaling pathway may regulate Par-dependent polarity in various biological contexts.

Publisher

Cold Spring Harbor Laboratory

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3