Neural circuits underlying habituation of visually evoked escape behaviors in larval zebrafish

Author:

Fotowat HalehORCID,Engert Florian

Abstract

AbstractLarval zebrafish that are exposed repeatedly to dark looming stimuli will quickly habituate to these aversive signals and cease to respond with their stereotypical escape swims.A dark looming stimulus can be separated into two independent components: one that is characterized by an overall spatial expansion, where overall luminance is maintained at the same level, and a second, that represents an overall dimming within the whole visual field in the absence of any motion energy. Using specific stimulation patterns that isolate these independent components, we first extracted the behavioral algorithms that dictate how these separate information channels interact with each other and across the two eyes during the habituation process. Concurrent brain wide imaging experiments then permitted the construction of circuit models that suggest the existence of three separate neural pathways. The first is a looming channel which responds specifically to concentrically expanding edges and relays that information to the brain stem escape network to generate directed escapes.The second is a dimming specific channel that serves to support and amplify the looming pathway. While the looming channel operates in a purely monocular fashion where stimuli are relayed exclusively to the contralateral hemisphere, dimming responses are processed in both monocular and binocular pathways. Finally, we identify a third, separate and largely monocular, dimming channel that appears to specifically inhibit escape responses when activated. We propose that, unlike the first two channels, this third channel is under strong contextual modulation and that it is primarily responsible for the incremental silencing of successive dark looming evoked escapes.

Publisher

Cold Spring Harbor Laboratory

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. A Visual Interface for Exploring Hypotheses about Neural Circuits;IEEE Transactions on Visualization and Computer Graphics;2023

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3