The association between the incidence of Lyme disease in the United States and indicators of greenness and land cover

Abstract

AbstractBackgroundLyme disease is the most common vector-borne illness in the United States. Incidence is related to specific environmental conditions such as temperature, metrics of land cover, and species diversity.ObjectiveTo determine whether greenness, as measured by the Normalized Difference Vegetation Index (NDVI), and other selected indices of land cover were associated with the incidence of Lyme disease in the northeastern USA, 2000-2018.Materials and MethodsWe conducted an ecological analysis of incidence rates in counties of 15 “high” incidence states and the District of Columbia for 2000-2018. Annual counts of Lyme disease by county were obtained from the US Centers for Disease Control and values of NDVI were acquired from the Moderate Resolution Imaging Spectroradiometer instrument aboard Terra and Aqua Satellites. County-specific values of population density, area of land and water were obtained from the US Census. Using quasi-Poisson regression, multivariable associations were estimated between the incidence of Lyme disease NDVI, land cover variables, human population density, and calendar year.ResultsWe found that incidence increased by 7.1% per year (95% confidence interval: 6.8-8.2%). Land cover variables showed complex non-linear associations with incidence: average county-specific NDVI showed a ‘u-shaped” association, the standard deviation of NDVI showed a monotonic upward relationship, population density showed a decreasing trend, areas of land and water showed “n”-shaped relationships. We found an interaction between average and standard deviation of NDVI, with the highest average NDVI category, increased standard deviation of NDVI showed the greatest increase in rates.DiscussionThese associations cannot be interpreted as causal but indicate that certain patterns of land cover may have the potential to increase exposure to infected ticks and thereby may contribute indirectly to increased rates. Public health interventions could make use of these results in informing people where risks may be high.