Time-course of population activity along the dorsoventral extent of the superior colliculus during delayed saccade tasks

Abstract

AbstractThe superior colliculus (SC) is an excellent substrate to study functional organization of sensorimotor transformations. We used linear multi-contact array recordings to analyze the spatial and temporal properties of population activity along the SC dorsoventral axis during delayed saccade tasks. During the visual epoch, information appeared first in dorsal layers and systematically later in ventral layers. In the ensuing delay period, the laminar organization of low-spiking rate activity matched that of the visual epoch. During the pre-saccadic epoch, spiking activity emerged first in a more ventral layer, ∼100ms before saccade onset. This buildup of activity appeared later on nearby neurons situated both dorsally and ventrally, culminating in a synchronous burst across the dorsoventral axis, ∼28ms before saccade onset. Stimulation of individual contacts on the laminar probe produced saccades of similar vectors. Collectively, the results reveal a principled spatiotemporal organization of SC population activity underlying sensorimotor transformation for the control of gaze.