Author:
Nagaraja R,MacMillan S,Kere J,Jones C,Griffin S,Schmatz M,Terrell J,Shomaker M,Jermak C,Hott C,Masisi M,Mumm S,Srivastava A,Pilia G,Featherstone T,Mazzarella R,Kesterson S,McCauley B,Railey B,Burough F,Nowotny V,D'Urso M,States D,Brownstein B,Schlessinger D
Abstract
A YAC/STS map of the X chromosome has reached an inter-STS resolution of 75 kb. The map density is sufficient to provide YACs or other large-insert clones that are cross-validated as sequencing substrates across the chromosome. Marker density also permits estimates of regional gene content and a detailed comparison of genetic and physical map distances. Five regions are detected with relatively high G + C, correlated with gene richness; and a 17-Mb region with very low recombination is revealed between the Xq13.3 [XIST] and Xq21.3 XY homology loci.
Publisher
Cold Spring Harbor Laboratory
Subject
Genetics (clinical),Genetics
Cited by
110 articles.
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