Author:
Papaioannou Virginia E.,Behringer Richard R.
Abstract
Viable homozygous mutant newborn mice may show effects of a mutation at any time during their development by exhibiting abnormal structure, function, or lethality. This overview guides the analysis of postnatal mice through gross anatomical assessment and the detection of visible phenotypes prior to weaning such as altered growth patterns, neurological problems, or abnormalities in movement or coordination. Advice on marking pups for identification purposes and providing adequate nutrition in the event of eating problems is given. After weaning and at the onset of puberty, different phenotypes may become manifest, including compromised growth and vigor and reproductive problems in males and/or females. Assessing infertility in each sex is addressed.
Publisher
Cold Spring Harbor Laboratory
Reference40 articles.
1. Effect of a Null Mutation of the c-fos Proto-Oncogene on Sexual Behavior of Male Mice1
2. Behringer RR , Gertsenstein M , Nagy KV , Nagy A . 2014. Manipulating the mouse embryo: a laboratory manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
3. Gene Expression Database. 2022. http://www.informatics.jax.org/expression.shtml [Accessed December 14, 2022].
4. Mouse P0 gene disruption leads to hypomyelination, abnormal expression of recognition molecules, and degeneration of myelin and axons
Cited by
3 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献