Abstract
AbstractThe flexible adjustment of ongoing behavior challenges the nervous system’s dynamic control mechanisms and has shown to be specifically susceptible to age-related decline. Previous work links endogenous gamma-aminobutyric acid (GABA) with behavioral efficiency across perceptual and cognitive domains, with potentially the strongest impact on those behaviors that require a high level of dynamic control. Based on the integrated analyses of behavior and modulation of interhemispheric phase-based connectivity during dynamic motor state transitions and endogenous GABA concentration, we provide converging evidence for age-related differences in the behaviorally more beneficial state of endogenous GABA concentration. We suggest that the increased interhemispheric connectivity seen in the older adults represents a compensatory mechanism caused by rhythmic entrainment of neural populations in homotopic motor cortices. This mechanism appears to be most relevant in the presence of a less optimal tuning of the inhibitory tone to uphold the required flexibility of behavioral action.
Publisher
Cold Spring Harbor Laboratory
Cited by
1 articles.
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