Graph-theoretical Analysis of EEG Functional Connectivity during Balance Perturbation in Traumatic Brain Injury: A Pilot Study

Abstract

AbstractTraumatic Brain Injury (TBI) often results in balance impairment, increasing the risk of falls, and the chances of further injuries. However, the underlying neurophysiological mechanisms of postural control after TBI are not well understood. To this end, we conducted a pilot study with a multimodal approach of EEG, MRI, and Diffusion Tensor Imaging (DTI) to explore the neural mechanisms of unpredictable balance perturbations in 17 chronic TBI participants and 15 matched Healthy Controls (HC). As quantitative measures of the functional integration and segregation of the brain networks during the postural task, we computed the global graph-theoretic network measures (global efficiency and modularity) of brain functional connectivity derived from source-space EEG in different frequency bands. We observed that the TBI group showed a lower balance performance as measured by the Center of Pressure (COP) displacement during the task, and the Berg Balance Scale. They also showed altered brain activation and connectivity during the balance task. In particular, the task modulation of brain network segregation in alpha-band was reduced in TBI. Moreover, the DTI findings revealed that the structural damage is associated with reduced network connectivity and integration. In terms of the neural correlates, we observed a distinct role played by different frequency bands; greater theta-band modularity during the task was strongly correlated with the BBS in TBI group; alpha-band and beta-band graph-theoretic measures were associated with the measures of white matter structural integrity. Our future studies will focus on how postural training will modulate the functional brain networks in TBI.