Sleep Enhances Neural Representations of True and False Memories: An Event-Related Potential Study

Abstract

AbstractEpisodic memory is reconstructive and is thus prone to false memory formation. Although false memories are proposed to develop via associative processes, the nature of their neural representations, and the effect of sleep on false memory processing is currently under debate. The present research employed the Deese-Roediger-McDermott (DRM) paradigm and a daytime nap to determine whether semantic false memories and true memories could be differentiated using event-related potentials (ERPs). We also sought to illuminate the role of sleep in memory formation and learning, with the use of a daytime nap. Healthy participants (N = 34, 28F, mean age = 23.23, range = 18-33) completed the DRM task with the learning and recognition phases separated by either a 2hr daytime nap or an equivalent wake period. Linear mixed modelling revealed larger LPC amplitudes for true memories in contrast to false memories, and larger P300 amplitudes for false compared to true memories. Those in the nap group also exhibited larger LPC and P300 amplitudes than participants in the wake group. Additionally, a larger P300 amplitude at delayed recognition (following a consolidation opportunity) was associated with increased true memory accuracy. These findings are argued to be reflective of sleep’s ability to promote pattern separation and pattern completion, with true memories arising from distinct memory traces, and false memories arising from thematic extraction and overlap in neural representations. The present research supports the perspective that both true and false memories are reflective of adaptive memory processes, whilst also suggesting that P300 amplitude affects episodic memory accuracy.