Scale-free models of chromosome structure, dynamics, and mechanics

Author:

Grosse-Holz SimonORCID,Coulon AntoineORCID,Mirny LeonidORCID

Abstract

Scale-free, or fractal, models are prevalent in the study of chromosome structure, dynamics, and mechanics. Recent experiments suggest the existence of scaling relationships; but currently there is no single model consistent with all observed exponents. We present a simple argument characterizing the space of scale-free models for chromosome structure, dynamics, and mechanics and discuss the implications for a consistent treatment. Our framework helps reconciling seemingly contradictory data and identifies specific experimental questions to be addressed in future work.

Publisher

Cold Spring Harbor Laboratory

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