Neighborhood air pollution is negatively associated with neurocognitive maturation in early adolescence

Abstract

AbstractThe ability to maintain focus and process task-relevant information continues developing during adolescence, but the specific physical environmental factors that influence this development remain poorly characterized. One candidate factor is air pollution. Evidence suggests that small particulate matter and NO2 concentrations in the air may negatively impact cognitive development in childhood. We assessed the relationship between neighborhood air pollution and the changes in performance on then-back task, a test of attention and working memory, in the Adolescent Brain Cognitive Development (ABCD) Study’s baseline (ages 9-10) and two-year-follow-up releases (Y2, ages 11-12; n = 5,256). In thebehavioraldomain, multiple linear regression showed that developmental change in n-back task performance was negatively associated with neighborhood air pollution (β = -.044, t = -3.11, p = .002), adjusted for covariates capturing baseline cognitive performance of the child, their parental income and education, family conflicts, and their neighborhood’s population density, crime rate, perceived safety, and Area Deprivation Index (ADI). The strength of the adjusted association for air pollution was similar to parental income, family conflict, and neighborhood ADI. In theneuroimagingdomain, we evaluated a previously published youthcognitivecomposite Connectome-based Predictive Model (ccCPM), and again found that decreased developmental change in the strength of the ccCPM from pre-to early adolescence was associated with neighborhood air pollution (β = -.110, t = -2.69, p = .007), adjusted for the covariates mentioned above and head motion. Finally, we found that the developmental change in ccCPM strength was predictive of the developmental change in n-back performance (r= .157, p < .001), and there was an indirect-only mediation where the effect of air pollution on change in n-back performance was mediated by the change in the ccCPM strength (βindirecteffect= -.013, p = .029). In conclusion, neighborhood air pollution is associated with lags in the maturation of youth cognitive performance and decreased strengthening of the brain networks supporting cognitive abilities over time.