Genome-wide association study stratified byMAPThaplotypes identifies potential novel loci in Parkinson’s disease

Abstract

AbstractObjectiveTo identify genetic factors that may modify the effects of theMAPTlocus in Parkinson’s disease (PD).MethodsWe used data from the International Parkinson’s Disease Genomics Consortium (IPDGC) and the UK biobank (UKBB). We stratified the IPDGC cohort for carriers of the H1/H1 genotype (PD patients n=8,492 and controls n=6,765) and carriers of the H2 haplotype (with either H1/H2 or H2/H2 genotypes, patients n=4,779 and controls n=4,849) to perform genome-wide association studies (GWASs). Then, we performed replication analyses in the UKBB data. To study the association of rare variants in the new nominated genes, we performed burden analyses in two cohorts (Accelerating Medicines Partnership – Parkinson Disease and UKBB) with a total sample size PD patients n=2,943 and controls n=18,486.ResultsWe identified a novel locus associated with PD amongMAPTH1/H1 carriers nearEMP1(rs56312722, OR=0.88, 95%CI= 0.84-0.92, p= 1.80E-08), and a novel locus associated with PD amongMAPTH2 carriers nearVANGL1(rs11590278, OR=1.69 95%CI=1.40-2.03, p= 2.72E-08). Similar analysis of the UKBB data did not replicate these results and rs11590278 nearVANGL1did have similar effect size and direction in carriers of H2 haplotype, albeit not statistically significant (OR= 1.32, 95%CI= 0.94-1.86, p=0.17). RareEMP1variants with high CADD scores were associated with PD in theMAPTH2 stratified analysis (p=9.46E-05), mainly driven by the p.V11G variant.InterpretationWe identified several loci potentially associated with PD stratified byMAPThaplotype and larger replication studies are required to confirm these associations.