Rapid protein-protein interaction network creation from multiple sequence alignments with Deep Learning-Reference-Cited by-同舟云学术

Rapid protein-protein interaction network creation from multiple sequence alignments with Deep Learning

Published:2023-04-17 Issue: Volume: Page:
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Author:

Bryant Patrick^ORCID,Noé Frank^ORCID

Abstract

AbstractAlphaFold2 (AF) can evaluate protein-protein interactions (PPIs) with high accuracy by finding evolutionary signals between proteins but comes with a high computational cost. Here, we speed up the prediction with AF for PPI network prediction 40x and reduce the disk space requirements 4000x for a set of 1000 proteins. Our protocol is easy to install and freely available from:https://github.com/patrickbryant1/SpeedPPI.

Publisher

Cold Spring Harbor Laboratory

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