Abstract
Serotonin is a neurotransmitter that signals through 5-HT receptors to control key functions in the nervous system. Serotonin receptors are also ubiquitously expressed in various organs and have been detected in embryos of different organisms. Potential morphogenetic functions of serotonin signaling have been proposed based on pharmacological studies but a mechanistic understanding is still lacking. Here, we uncover a role of serotonin signaling in axis extension ofDrosophilaembryos by regulating MyosinII (MyoII) activation, cell contractility and cell intercalation. We find that serotonin and serotonin receptors 5HT2A and 5HT2B form a signaling module that quantitatively regulates the amplitude of planar polarized MyoII contractility specified by Toll receptors and the GPCR Cirl. Remarkably, serotonin signaling also regulates actomyosin contractility at cell junctions, cellular flows and epiblast morphogenesis during chicken gastrulation. This phylogenetically conserved mechanical function of serotonin signaling in regulating actomyosin contractility and tissue flow reveals an ancestral role in morphogenesis of multicellular organisms.
Publisher
Cold Spring Harbor Laboratory
Reference87 articles.
1. The action of neurotransmitters and related substances on early embryogenesis;Pharmacology & therapeutics,1984
2. THE R OLE OF NEUROHUMOURS IN EARLY EMBRYOGENESIS. I. SEROTONIN CONTENT OF DEVELOPING EMBRYOS OF SEA URCHIN AND LOACH;Journal of embryology and experimental morphology,1964
3. Presence in and effects of pineal indoleamines at very low level of phylogeny
4. The serotonergic system in Tetrahymena pyriformis;La Ricerca in clinica e in laboratorio,1987
5. How does the unicellular Tetrahymena utilise the hormones that it produces? Paying a visit to the realm of atto-and zeptomolar concentrations;Cell and tissue research,2007
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