Antifungal activities of artesunate, chloramphenicol, and cotrimoxazole against Basidiobolus species, the causal agents of gastrointestinal basidiobolomycosis

Author:

Al-Qahtani Saleh,Joseph Martin R.P.,Al Hakami Ahmed M.,Asseri Ali A.,Mathew Anjali,Al Bshabshe Ali,Alhumayed Suliman,Hamid Mohamed E.

Abstract

AbstractBasidiobolus species (n =13) isolated from human gastrointestinal basidiobolomycosis and lizards were tested against artesunate, chloramphenicol, and cotrimoxazole. The three agents exhibited inhibitory actions against Basidiobolus species comparable to the known antifungals. The combined effects of artesunate + voriconazole and cotrimoxazole + voriconazole have significant synergic effects, p = 0.003 and p = 0.021, respectively. These are promising results that enhance accelerated combined treatment of GIB in humans particularly the combination of artesunate and voriconazole.

Publisher

Cold Spring Harbor Laboratory

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Atypical presentation of Basidiobolus as cutaneous ulceration;Journal of Skin and Sexually Transmitted Diseases;2024-01-18

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