Author:
Al-Qahtani Saleh,Joseph Martin R.P.,Al Hakami Ahmed M.,Asseri Ali A.,Mathew Anjali,Al Bshabshe Ali,Alhumayed Suliman,Hamid Mohamed E.
Abstract
AbstractBasidiobolus species (n =13) isolated from human gastrointestinal basidiobolomycosis and lizards were tested against artesunate, chloramphenicol, and cotrimoxazole. The three agents exhibited inhibitory actions against Basidiobolus species comparable to the known antifungals. The combined effects of artesunate + voriconazole and cotrimoxazole + voriconazole have significant synergic effects, p = 0.003 and p = 0.021, respectively. These are promising results that enhance accelerated combined treatment of GIB in humans particularly the combination of artesunate and voriconazole.
Publisher
Cold Spring Harbor Laboratory
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