The dynamics of human cognition: increasing global integration coupled with decreasing segregation found using iEEG

Abstract

AbstractCognitive processing requires the ability to flexibly integrate and process information across large brain networks. More information is needed on how brain networks dynamically reorganize to allow such broad communication across many different brain regions in order to integrate the necessary information. Here, we use intracranial EEG to record neural activity from 12 epileptic patients while they perform three cognitive tasks in order to study how the functional connectivity changes to facilitate communication across the underlying network spanning many different brain regions. At the topological level, this facilitation is characterized by measures of integration and segregation. Across all patients, we found significant increases in integration and decreases in segregation during cognitive processing, especially in the gamma band (50-90 Hz). Accordingly, we also found significantly higher level of global synchronization and functional connectivity during the execution of the cognitive task, again particularly in the gamma band. More importantly, we demonstrate here for the first time that the modulations at the level of functional connectivity facilitating communication across the network were not caused by changes in the level of the underlying oscillations but caused by a rearrangement of the mutual synchronisation between the different nodes as proposed by the “Communication Through Coherence” Theory.