Early empirical assessment of the N501Y mutant strains of SARS-CoV-2 in the United Kingdom, October to November 2020-Reference-Cited by-同舟云学术

Early empirical assessment of the N501Y mutant strains of SARS-CoV-2 in the United Kingdom, October to November 2020

Published:2020-12-22 Issue: Volume: Page:
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Author:

Leung Kathy,Shum Marcus HH,Leung Gabriel M^ORCID,Lam Tommy TY^ORCID,Wu Joseph T^ORCID

Abstract

AbstractTwo new SARS-CoV-2 lineages with the N501Y mutation in the receptor binding domain of the spike protein have rapidly become prevalent in the UK. We estimated that the earlier 501Y lineage without amino acid deletion Δ69/Δ70 circulating mainly between early September to mid-November was 10% (6-13%) more transmissible than the 501N lineage, and the currently dominant 501Y lineage with amino acid deletion Δ69/Δ70 circulating since late September was 75% (70-80%) more transmissible than the 501N lineage.

Publisher

Cold Spring Harbor Laboratory

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