In vitro assessment of the capacity of pesticides to act as agonists/antagonists of the thyroid hormone nuclear receptors-Reference-Cited by-同舟云学术

In vitro assessment of the capacity of pesticides to act as agonists/antagonists of the thyroid hormone nuclear receptors

Published:2020-12-22 Issue: Volume: Page:
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Author:

Zekri Yanis,Agnol Laure Dall,Flamant Frédéric^ORCID,Guyot Romain^ORCID

Abstract

SummarySeveral in vitro tests, including transcriptome analysis of neural cells, were performed to assess the capacity of 33 pesticides to act as thyroid hormone disruptors (THD). Although some pesticides elicit a cellular response, which interferes with thyroid hormone signaling, we found no evidence that they can act as receptor agonists or antagonists. We conclude that the nuclear receptors of thyroid hormone are not common targets of THD, and that pesticide neurodevelopmental toxicity is not explained by a general alteration of neural cell response to thyroid hormone.

Publisher

Cold Spring Harbor Laboratory

Reference37 articles.

1. Gilbert, M. , O’Shaughnessy, K. , Axelstad, M. (2020) Regulation of Thyroid Disrupting Chemicals to Protect the Developing Brain. Endocrinology.

2. Laureano-Melo, R. , Souza, J. S. , da Conceicao, R. R. , Albuquerque, J. M. L. (2019) Prenatal thyroxine treatment promotes anxiolysis in male Swiss mice offspring. Horm Behav, pp 10–19.

3. Yen, P. M. , Ando, S. , Feng, X. , Liu, Y. (2006) Thyroid hormone action at the cellular, genomic and target gene levels. Mol Cell Endocrinol, pp 121–127.

4. Perissi, V. , Rosenfeld, M. G. (2005) Controlling nuclear receptors: the circular logic of cofactor cycles. Nat Rev Mol Cell Biol, pp 542–554.

5. Toporova, L. , Balaguer, P. (2020) Nuclear receptors are the major targets of endocrine disrupting chemicals. Mol Cell Endocrinol, p 110665.