Activity-Dependent Modulation of Synapse-Regulating Genes in Astrocytes

Author:

Farhy-Tselnicker I,Boisvert MM,Liu H,Dowling C,Erikson GA,Blanco-Suarez E,Farhy C,Shokhirev M,Ecker JR,Allen NJ

Abstract

SummaryAstrocytes regulate the formation and function of neuronal synapses via multiple signals, however, what controls regional and temporal expression of these signals during development is unknown. We determined the expression profile of astrocyte synapse-regulating genes in the developing mouse visual cortex, identifying astrocyte signals that show differential temporal and layer-enriched expression. These patterns are not intrinsic to astrocytes, but regulated by visually-evoked neuronal activity, as they are absent in mice lacking glutamate release from thalamocortical terminals. Consequently, synapses remain immature. Expression of synapse-regulating genes and synaptic development are also altered when astrocyte signaling is blunted by diminishing calcium release from astrocyte stores. Single nucleus RNA sequencing identified groups of astrocytic genes regulated by neuronal and astrocyte activity, and a cassette of genes that show layer-specific enrichment. Thus, the development of cortical circuits requires coordinated signaling between astrocytes and neurons, identifying astrocytes as a target to manipulate in neurodevelopmental disorders.

Publisher

Cold Spring Harbor Laboratory

Cited by 2 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. From Synapses to Circuits, Astrocytes Regulate Behavior;Frontiers in Neural Circuits;2022-01-04

2. Development of astrocyte morphology and function in mouse visual thalamus;Journal of Comparative Neurology;2021-10-25

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