Author:
Huang Kang,Dunn Derek W.,Li Wenkai,Wang Dan,Li Baoguo
Abstract
AbstractThe influence of genetic drift on linkage disequilibrium in finite populations has been extensively studied in diploids. However, to date the effects of ploidy on LD has not been extensively studied. We here extend the linkage disequilibrium measureDand Burrow’s Δ statistic to include polysomic inheritance, as well as their corresponding squared correlation coefficientsr2and, where the former is for phased genotypes and the latter for unphased genotypes. Weir & Hill’s double non-identity framework is also extended to include polysomic inheritance, and the expressions of double non-identity coefficients are derived under five mating systems. On this basis, the approximated expectations of estimatedr2andat equilibrium state,d2andδ2, are derived under five mating systems. We assess the behaviors of the estimatedr2andand the influence of the recombination rate ond2orδ2, simulate the application of estimating effective population size, and evaluate the statistical performance of the method of estimating.
Publisher
Cold Spring Harbor Laboratory
Reference32 articles.
1. Multilocus structure of natural populations of Hordeum spontaneum;Genetics,1980
2. Transmission genetics of chromatin from a synthetic amphidiploid to cultivated peanut (Arachis hypogaea L.): broadening the gene pool of a monophyletic polyploid species;Genetics,2001
3. Selection-mutation balance in polysomic tetraploids: Impact of double reduction and gametophytic selection on the frequency and subchromosomal localization of deleterious mutations
4. Digenic descent measures for finite populations;Genetics Research,1977
5. A Comparison of Linkage Disequilibrium Measures for Fine-Scale Mapping