Do Motoneurons’ Discharge Rate Slow With Aging? A Systematic Review And Meta-Analysis

Abstract

AbstractNervous system maladaptation is linked to the loss of maximal strength production and motor control with aging. Motor unit discharge rates are a critical determinant of force production; thus, lower discharge rates could be a mechanism underpinning maximal strength and motor control losses during aging. This meta-analysis summarized the findings of studies comparing motor unit discharge rates between young and older adults, and examined the effect of distinct muscles and contraction intensities on the magnitude of discharge rates difference between these two groups. Eligible studies were combined in a meta-analysis, including tested contraction intensities and muscles in different levels, to investigate whether there were differences in discharge rates between younger and older adults. Motor unit discharge rates were higher in younger adults compared to older adults, with a pooled standardized mean difference (SMD) for all studies of 0.63 (95%CI= 0.27 to 0.99). Contraction intensity had a significant effect on the pooled SMD, with a 1% increase in intensity associated with a 0.009 (95%CI= 0.003 to 0.015) change in the pooled SMD. These findings suggest that the reductions in motor unit discharge rates, especially at higher contraction intensities, may be an important mechanism underpinning age-related losses in maximal strength production.