Prolonged and extended impacts of SARS-CoV-2 on the olfactory neurocircuit-Reference-Cited by-同舟云学术

Prolonged and extended impacts of SARS-CoV-2 on the olfactory neurocircuit

Published:2021-11-05 Issue: Volume: Page:
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Author:

Kishimoto-Urata Megumi,Urata Shinji,Kagoya Ryoji,Imamura Fumiaki,Nagayama Shin,Reyna Rachel A.^ORCID,Maruyama Junki^ORCID,Yamasoba Tatsuya,Kondo Kenji,Hasegawa-Ishii Sanae,Paessler Slobodan

Abstract

AbstractThe impact of SARS-CoV-2 on the olfactory pathway was studied over several time points using Syrian golden hamsters. We found an incomplete recovery of the olfactory sensory neurons, prolonged activation of glial cells in the olfactory bulb, and a decrease in the density of dendritic spines within the hippocampus. These data may be useful for elucidating the mechanism underlying long-lasting olfactory dysfunction and cognitive impairment as a post-acute COVID-19 syndrome.

Publisher

Cold Spring Harbor Laboratory

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