Integrated resource for functional and structural connectivity of the marmoset brain

Abstract

AbstractThe comprehensive integration of structural and functional connectivity data is required for the accurate modeling of brain functions. While resources for studying structural connectivity of non-human primate marmoset brains already exist, their integration with functional connectivity data has remained unavailable. Therefore, we present a comprehensive resource for marmoset brain mapping, which integrates the largest awake resting-state fMRI dataset to date (39 marmosets, 709 runs, and 12053 mins), cellular- level neuronal-tracing dataset (52 marmosets and 143 injections), and multi-resolution diffusion MRI dataset. The combination of these data into the same MRI space allowed us to 1). map the fine-detailed functional networks and cortical parcellations; 2). develop a deep-learning-based parcellation generator to preserve the topographical organization of functional connectivity and reflect individual variabilities; 3). investigate the structural basis underlying functional connectivity by computational modeling. Our resource will broadly model the marmoset brain architecture and facilitate future comparative and translational studies of primate brains.