Feasibility and safety of shortened hypofractionated high dose palliative lung radiotherapy – A retrospective planning study

Author:

Jones MatthewORCID,Rogers JaneORCID,Shrimali Raj KumarORCID,Hamilton Jo,Athmanathan Senthil,Jones Bleddyn

Abstract

AbstractObjectiveAssess the safety and feasibility of shortened hypo-fractionated high dose palliative lung radiotherapy in a retrospective planning study.MethodsFifteen palliative lung radiotherapy patients previously treated with the standard 36 Gy in 12 fractions (12F) schedule were non-randomly selected to achieve a representative distribution of tumour sizes, volumes, locations and staging. Plans were produced using 30 Gy in 5 fractions (5F) and 30 Gy in 6 fractions (6F) using a 6MV FFF co-planar VMAT technique. These plans were optimised to meet dose constraints for both PTVs and OARs where established OAR constraints were expressed as BED. The potential safety of the delivery of these plans was assessed using these BEDs and also with reductions of 10% and 20% to account for effects of chemotherapy or surgery.ResultsFor all 5F and 6F plans the mandatory constraints using the full BED were met, as with all 6F plans with 10% BED reductions, but reduced to 6 patients using 5F. Three of 15 5F and 6 of 15 6F plans met the 20% BED reductions.ConclusionIt is potentially safe and feasible to deliver high dose palliative radiotherapy using the 5F or 6F regimes described, when carefully planned to comparable OAR BEDs as for 12F standard. It appears that the toxicity from either of these regimes should be within acceptable limits provided that the dose constraints described can be adhered to. A Phase II study would be required to fully assess the safety and feasibility. The outcomes from such a study could potentially reduce the number of patient hospital visits for radiotherapy, thus benefiting the patient and the clinical service by optimising resource utilisation.Advances in KnowledgeShortened hypo-fractionated high dose palliative lung radiotherapy is technically feasible provided OAR constraints are respected.

Publisher

Cold Spring Harbor Laboratory

Reference42 articles.

1. Cancer statistics, 2015

2. Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012

3. Cancer registration statistics, England: 2017 [Internet]. Office for National Statistics; 2019 Apr. Available from: https://www.ons.gov.uk/peoplepopulationandcommunity/healthandsocialcare/conditionsanddiseases/bulletins/cancerregistrationstatisticsengland/2017

4. Lung cancer statistics [Internet]. Cancer Research UK; [cited 2021 May 25]. Available from: https://www.cancerresearchuk.org/health-professional/cancer-statistics/statistics-by-cancer-type/lung-cancer/incidence%23heading-Three

5. National Cancer Registration & Analysis Service and Cancer Research UK: “Chemotherapy, Radiotherapy and Tumour Resections in England: 2013-2014” workbook. London: NCRAS; 2017.

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3