Author:
Gaboli Mirella,Kotsi Paraskevi A.,Gurrieri Carmela,Cattoretti Giorgio,Ronchetti Simona,Cordon-Cardo Carlos,Broxmeyer Hal E.,Hromas Robert,Pandolfi Pier Paolo
Abstract
MZF1 is a transcription factor belonging to the Krüppelfamily of zinc finger proteins, expressed in totipotent hemopoietic cells as well as in myeloid progenitors. Here we have inactivatedMzfi1 by gene targeting. Mzf1−/− mice develop lethal neoplasias characterized by the infiltration and complete disruption of the liver architecture by a monomorphic population of cells of myeloid origin reminiscent of human chloromas.Mzf1 inactivation results in a striking increase of the autonomous cell proliferation and of the ability ofMzf1−/− hemopoietic progenitors to sustain long-term hemopoiesis. These findings demonstrate that Mzf1 can act as a tumor/growth suppressor in the hemopoietic compartment.
Publisher
Cold Spring Harbor Laboratory
Subject
Developmental Biology,Genetics
Reference23 articles.
1. Plzf regulates limb and axial skeletal patterning
2. Antisense oligonucleotides from the stage-specific myeloid zinc finger gene MZF-1 inhibit granulopoiesis in vitro.
3. Expression or the retinoblastoma protein is regulated in normal human tissue.;Cordon-Cardo;Am. J. Pathol.,1994
4. Pten and p27KIP1 cooperate in prostate cancer tumor suppression in the mouse
5. Harrison T.R. (1987) The leukemias. in Harrison's principles of internal medicine, eds Braunwald E. Isselbacher K.J. Petersdorf R.G. Wilson J.D. Martin J.B. Fauci A.S. (McGraw-Hill Book Company, New York), 11th ed. pp 1545–1589.
Cited by
116 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献