Author:
Wang Baihan,Pozarickij Alfred,Mazidi Mohsen,Wright Neil,Yao Pang,Said Saredo,Iona Andri,Kartsonaki Christiana,Fry Hannah,Lin Kuang,Chen Yiping,Du Huaidong,Avery Daniel,Schmidt Dan Valle,Yu Canqing,Sun Dianjianyi,Lv Jun,Hill Michael,Li Liming,Bennett Derrick A,Collins Rory,Walters Robin G,Clarke Robert,Millwood Iona Y,Chen Zhengming
Abstract
AbstractProteomics offers unique insights into human biology and drug development, but few studies have directly compared the utility of different proteomics platforms. We measured 2,168 plasma proteins in 3,976 Chinese adults using both OLINK and SomaScan platforms and compared their genetic determinants and associations with traits and disease risk. For 1,694 proteins with one-to-one matched reagents, there was a modest between platform correlation (median rho=0.20). OLINK-proteins had fewertrans-pQTLs (766 vs 812 proteins) but morecis-pQTLs (725 vs 565) than SomaScan-proteins, including 342 with colocalisingcis-pQTLs. Moreover, 1,095 OLINK- and 963 SomaScan-proteins showed significant associations with BMI, while 279 and 165 proteins were significantly associated with IHD, respectively. Addition of these IHD-associated proteins to conventional risk factors yielded NRIs for IHD of 15.3% and 17.1% for OLINK and SomaScan respectively. The results demonstrate the complementarity of different proteomic platforms and should inform assay selection in future population and clinical studies.
Publisher
Cold Spring Harbor Laboratory