Influence of heterogeneous myelination patterns on axonal conduction and vulnerability to demyelination

Author:

Talidou Afroditi,Lefebvre Jérémie

Abstract

AbstractAxons of the mammalian brain display significant variations in their myelination motifs. Far from being regular and uniform, the distribution patterns of myelin sheaths vary significantly between axons, and across brain areas. To explore the influence of such variability on axonal conduction, we developed an axon model exhibiting myelin distributions mirroring those observed experimentally in different regions of the central nervous system of mice. We also examined how varying myelination patterns predispose axons to failure. Our study shows such variability significantly impacts axonal conduction timing and reliability. Action potential propagation was found to be highly sensitive to the specific arrangement and ordering of myelinated and/or exposed segments along axons, indicating that axonal conduction is non-linear and path-dependent. Furthermore, properties of axonal conduction were found to differ between cortical and callosal axons, influencing their vulnerability to demyelination, while shaping both conduction time and predisposition to failure. Our analysis indicates that callosal axons are particularly sensitive to myelin changes, especially after damage. These findings highlight the crucial role of myelination profiles in brain function and disease.

Publisher

Cold Spring Harbor Laboratory

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3