Knockdown resistance (kdr) Associated organochlorine Resistance in mosquito-borne diseases (Culex pipiens): Systematic study of reviews and meta-analysis

Abstract

AbstractBackgroundCulex pipiensis the vector of a large number of pathogenic pathogens in humans. Using insecticides to deal with this vector is the most important way to control it. However, in recent decades, resistance to insecticides has been reported in this vector. One of the main insecticides used to fight this vector is organochlorine insecticides. Based on this, this study was conducted to investigate the prevalence of Knockdown resistance (kdr) inCulex pipiensagainst organochlorine insecticides.MethodsThis study was conducted by systematic review and meta-analysis in the field of kdr prevalence inCulex pipiensagainst organochlorine insecticides. Based on this, during the search in the scientific databases PubMed, Web of Science, biooan.org, Embase, ProQuest, Scopus, and Google Scholar without time limit until the end of November 2023, all related articles were extracted and analyzed. The statistical analysis of the data was performed using the random and fixed effects model in the meta-analysis, Cochran’s test,I2index, and meta-regression by STATA software version 17.Resultsseven studies with a sample size of 2,029Culex pipienswere included in the meta-analysis process. Based on the findings, the kdr resistance prevalence against Deltamethrin, Malathion, Permethrin, and DDT insecticides was estimated as 30.6%, 42%, 17.9%, and 76.3% respectively. Among them, the highest resistance to DDT and the lowest to Permethrin was observed.ConclusionBased on the findings, a large proportion ofCulex pipiensmosquitoes were resistant to DDT insecticide. However, this vector was highly sensitive to Deltamethrin, Malathion, and Permethrin insecticides. Due to the different resistance ratios in different regions of the world, it is recommended to conduct studies on the prevalence of kdr inCulex pipiens.