MOCAT: Multi-Omics Integration with Auxiliary Classifiers Enhanced Autoencoder

Abstract

AbstractBackgroundIntegrating multi-omics data is emerging as a critical approach in enhancing our understanding of complex diseases. Innovative computational methods capable of managing high-dimensional and heterogeneous datasets are required to unlock the full potential of such rich and diverse data.MethodsWe propose a Multi-Omics integration framework with auxiliary Classifiers-enhanced AuToencoders (MOCAT), for comprehensive utilization of both intra- and inter-omics information. Additionally, attention mechanisms with confidence learning are incorporated for enhanced feature representation and trustworthy prediction.ResultsExtensive experiments were conducted on four benchmark datasets to evaluate the effectiveness of our proposed model, including BRCA, ROSMAP, LGG, and KIPAN. Our model significantly improved most evaluation measurements and consistently surpassed the state-of-the-art methods. Ablation studies showed that the auxiliary classifiers significantly boosted classification accuracy in both the ROSMAP and LGG datasets. Moreover, the attention mechanisms and confidence evaluation block contributed to improvements in the predictive accuracy and generalizability of our model.ConclusionsThe proposed framework exhibits superior performance in disease classification and biomarker discovery, establishing itself as a robust and versatile tool for analyzing multi-layer biological data. This study highlights the significance of elaborated designed deep learning methodologies in dissecting complex disease phenotypes and improving the accuracy of disease predictions.