Author:
Dieng Idrissa,Ndiaye Mignane,Kane Mouhamed,Balde Diamilatou,Mbanne Maimouna,Diop Seynabou Mbaye Ba Souna,Sankhe Safietou,Dia Moussa,Dieng Madeleine,Doukanda Serge Freddy Moukaha,Faye Ousmane,Sall Amadou Alpha,Dia Ndongo,Fall Gamou,Faye Oumar,Diagne Moussa Moise
Abstract
AbstractThe Chikungunya virus, a global arbovirus, is currently causing a major outbreak in the Western African region, with the highest cases reported in Senegal and Burkina Faso. Recent molecular evolution analyses reveal that the strain responsible for the epidemic belongs to the West African genotype, with new mutations potentially impacting viral replication, antigenicity, and host adaptation. Real-time genomic monitoring is needed to track the virus’s spread in new regions. A scalable West African genotype amplicon-based Whole Genome Sequencing for multiple Next Generation Sequencing platforms has been developed to support genomic investigations and identify epidemiological links during the virus’s ongoing spread. This technology will help identify potential threats and support real-time genomic investigations in the ongoing spread of the virus.
Publisher
Cold Spring Harbor Laboratory