A Comprehensive Allele Specific Expression Resource for the Equine Transcriptome

Author:

Heath Harrison D.,Peng Sichong,Szmatola Tomasz,Bellone Rebecca R.,Kalbfleisch Theodore,Petersen Jessica L.,Finno Carrie J.ORCID

Abstract

AbstractBackgroundAllele-specific expression (ASE) analysis provides a nuanced view of cis-regulatory mechanisms affecting gene expression.ResultsIn this work, we introduce and highlight the significance of an equine ASE analysis, containing integrated long- and short-read RNA sequencing data, along with insight from histone modification data, from four healthy Thoroughbreds (2 mares and 2 stallions) across 9 tissues.ConclusionsThis valuable publicly accessible resource is poised to facilitate investigations into regulatory variation in equine tissues and foster a deeper understanding of the impact of allelic imbalance in equine health and disease at the molecular level.

Publisher

Cold Spring Harbor Laboratory

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