Abstract
AbstractThe Four Core Genotypes (FCG) is a mouse model system heavily used to disentangle the function of sex chromosomes and hormones. We report that a copy of a 3.2 MB region of the X chromosome has translocated to the YSry-chromosome and thus increased the expression of multiple genes including the auto-immune master regulatorTlr7. This previously-unreported X-Y translocation complicates the interpretation of studies reliant on FCG mice.
Publisher
Cold Spring Harbor Laboratory