Abstract
AbstractAlternative splicing is the post-transcriptional mechanism by which many different isoforms are generated from a single gene, contributing to increasing spatio-temporal transcriptome complexity. We propose a novel genome-level measure of alternative splicing, which associates it with a single value for each species. Thus, a comparative analysis of species spanning the whole tree of life has revealed certain evolutionary trends in alternative splicing, prevalence in specific lineages, and relation to genome compositional structures.
Publisher
Cold Spring Harbor Laboratory