Author:
Serre David,Nadon Robert,Hudson Thomas J.
Abstract
In humans, most recombination events occur in a small fraction of the genome. These hotspots of recombination show considerable variation in intensity and/or location across species and, potentially, across human populations. On a larger scale, the patterns of recombination rates have been mostly investigated in individuals of European ancestry, and it remains unknown whether the results obtained can be directly applied to other human populations. Here, we investigate this question using genome-wide polymorphism data. We show that population recombination rates recapitulate a large part of the genetic map information, regardless of the population considered. We also show that the ratio of the population recombination rate estimate of two populations is overall constant along the chromosomes. These two observations support the hypothesis that large-scale recombination patterns are conserved across human populations. Local deviations from the overall pattern of conservation of the recombination rates can be used to select candidate regions with large polymorphic inversions or under local selection.
Publisher
Cold Spring Harbor Laboratory
Subject
Genetics (clinical),Genetics
Reference30 articles.
1. Population History and Natural Selection Shape Patterns of Genetic Variation in 132 Genes
2. Box, G.E.P, Jenkins, G.M., and Reinsel, G.C. 1994. Time series analysis: Forecasting and control, 3rd ed. Prentice-Hall, Upper Saddle River, NJ.
3. Comprehensive Human Genetic Maps: Individual and Sex-Specific Variation in Recombination
4. Cohen, J., Cohen, P., West, S.G., and Aiken, L.S. 2003. Applied multiple regression/correlation analysis for the behavioral sciences, 3rd ed. LEA Publishers, Mahwah, NJ.
5. Evidence for substantial fine-scale variation in recombination rates across the human genome
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