Abstract
AbstractSorghum and maize share a close evolutionary history that can be explored through comparative genomics. To perform a large-scale comparison of the genomic variation between these two species, we analyzed 13 million variants identified from whole genome resequencing of 468 sorghum lines together with 25 million variants previously identified in 1,218 maize lines. Deleterious mutations in both species were prevalent in pericentromeric regions, enriched in non-syntenic genes, and present at low allele frequencies. A comparison of deleterious burden between sorghum and maize revealed that sorghum, in contrast to maize, departed from the “domestication cost” hypothesis that predicts a higher deleterious burden among domesticates compared to wild lines. Additionally, sorghum and maize population genetic summary statistics were used to predict a gene deleterious index with an accuracy higher than 0.5. This research represents a key step towards understanding the evolutionary dynamics of deleterious variants in sorghum and provides a comparative genomics framework to start prioritizing them for removal through genome editing and breeding.
Publisher
Cold Spring Harbor Laboratory
Reference59 articles.
1. Genome Alignment Spanning Major Poaceae Lineages Reveals Heterogeneous Evolutionary Rates and Alters Inferred Dates for Key Evolutionary Events
2. Close Split of Sorghum and Maize Genome Progenitors
3. Fuller, D. Q. & Stevens, C. J. Sorghum Domestication and Diversification: A Current Archaeobotanical Perspective. in Plants and People in the African Past: Progress in African Archaeobotany (eds. Mercuri, A. M. , D’Andrea, A. C. , Fornaciari, R. & Höhn, A. ) 427–452 (Springer International Publishing, 2018).
4. Genetic diversity, structure, gene flow and evolutionary relationships within the Sorghum bicolor wild-weedy-crop complex in a western African region;Theor. Appl. Genet.,2011
5. Whole-genome sequencing reveals untapped genetic potential in Africa’s indigenous cereal crop sorghum