Dorsal Periaqueductal gray ensembles represent approach and avoidance states

Author:

Reis Fernando MCVORCID,Lee Johannes YORCID,Maesta-Pereira Sandra,Schuette Peter J,Chakerian Meghmik,Liu Jinhan,La-Vu Mimi Q,Tobias Brooke C,Canteras Newton S,Kao Jonathan CORCID,Adhikari AvishekORCID

Abstract

AbstractAnimals must balance needs to approach threats for risk-assessment and to avoid danger. The dorsal periaqueductal gray (dPAG) controls defensive behaviors, but it is unknown how it represents states associated with threat approach and avoidance. We identified a dPAG threat-avoidance ensemble in mice that showed higher activity far from threats such as the open arms of the elevated plus maze and a live predator. These cells were also more active during threat-avoidance behaviors such as escape and freezing, even though these behaviors have antagonistic motor output. Conversely, the threat-approach ensemble was more active during risk-assessment behaviors and near threats. Furthermore, unsupervised methods showed approach/avoidance states were encoded with shared activity patterns across threats. Lastly, the relative number of cells in each ensemble predicted threat-avoidance across mice. Thus, dPAG ensembles dynamically encode threat approach and avoidance states, providing a flexible mechanism to balance risk-assessment and danger avoidance.

Publisher

Cold Spring Harbor Laboratory

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