Abstract
ABSTRACTOBJECTIVETo examine whether the age distribution of COVID-19 deaths and the share of deaths in nursing homes changed in the second versus the first pandemic wave.ELIGIBLE DATAWe considered all countries that had at least 4000 COVID-19 deaths occurring as of January 14, 2020, at least 200 COVID-19 deaths occurring in each of the two epidemic wave periods; and which had sufficiently detailed information available on the age distribution of these deaths. We also considered countries with data available on COVID-19 deaths of nursing home residents for the two waves.MAIN OUTCOME MEASURESChange in the second wave versus the first wave in the proportion of COVID-19 deaths occurring in people <50 years (“young deaths”) among all COVID-19 deaths and among COVID-19 deaths in people <70 years old; and change in the proportion of COVID-19 deaths in nursing home residents among all COVID-19 deaths.RESULTSData on age distribution were available for 14 eligible countries. Individuals <50 years old had small absolute difference in their share of the total COVID-19 deaths in the two waves across 13 high-income countries (absolute differences 0.0-0.4%). Their proportion was higher in Ukraine, but it decreased markedly in the second wave. The odds of young deaths was lower in the second versus the first wave (summary odds ratio 0.80, 95% CI 0.70-0.92) with large between-country heterogeneity. The odds of young deaths among deaths <70 years did not differ significantly across the two waves (summary odds ratio 0.95, 95% CI 0.85-1.07). Eligible data on nursing home COVID-19 deaths were available for 11 countries. The share of COVID-19 deaths that were accounted by nursing home residents decreased in the second wave significantly and substantially in 8 countries (odds ratio estimates: 0.22 to 0.66), remained the same in Denmark and Norway and markedly increased in Australia.CONCLUSIONSIn the examined countries, age distribution of COVID-19 deaths has been fairly similar in the second versus the first wave, but the contribution of COVID-19 deaths in nursing home residents to total fatalities has decreased in most countries in the second wave.
Publisher
Cold Spring Harbor Laboratory
Reference26 articles.
1. Williamson E , Walker AJ , Bhaskaran KJ , Bacon S , Bates C , Morton CE , et al. OpenSAFELY: factors associated with COVID-19-related hospital death in the linked electronic health records of 17 million adult NHS patients. medRxiv. 2020:2020.05.06.20092999.
2. Ioannidis JPA , Axfors C , Contopoulos-Ioannidis DG . Population-level COVID-19 mortality risk for non-elderly individuals overall and for non-elderly individuals without underlying diseases in pandemic epicenters. Environmental research. 2020;188:109890.
3. O’Driscoll M , Dos Santos GR , Wang L , Cummings DAT , Azman AS , Paireau J , et al. Age-specific mortality and immunity patterns of SARS-CoV-2. Nature. 2020.
4. Ioannidis JPA . Precision shielding for COVID-19: metrics of assessment and feasibility of deployment. medRxiv. 2020:2020.11.01.20224147.
5. Gudbjartsson DF , Helgason A , Jonsson H , Magnusson OT , Melsted P , Norddahl GL , et al. Spread of SARS-CoV-2 in the Icelandic Population. The New England journal of medicine. 2020.