Positive feedback regulation ofPparγ1svandPparγ2during adipogenesis in 3T3-L1 cells

Abstract

AbstractWe have previously identified the novel splicing variant of mousePparγ(Pparγ1sv) and proposed the synergistic regulation of the early stage of adipocyte differentiation byPparγ1svandPparγ2. Here, we report the finding of PPARγ-binding sites within thePparγgene locus and its importance in adipogenesis and propose the positive feedback regulation ofPparγ1svandPparγ2expression during the adipocyte differentiation of 3T3-L1 cells.