Abstract
AbstractNeurons migrate through repeated leading process extension and somal translocation, yet how they coordinate these movements remains unknown. Here, we demonstrate that leading process extension increases plasma membrane tension and triggers Ca2+influx via mechanosensitive ion channels, leading to actomyosin contraction for somal translocation. Thus, membrane tension transduces the change in the leading process length into a force that drives somal translocation, allowing saltatory and efficient movement of neuronal migration.
Publisher
Cold Spring Harbor Laboratory