Plasma CXCL8 and MCP-1 as biomarkers of latent tuberculosis infection-Reference-Cited by-同舟云学术

Plasma CXCL8 and MCP-1 as biomarkers of latent tuberculosis infection

Published:2023-08-09 Issue: Volume: Page:
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Selvavinayagam Sivaprakasam T,Aswathy Bijulal,Yong Yean K,Frederick Asha,Murali Lakshmi,Kalaivani Vasudevan,Jith Karishma S,Rajeshkumar Manivannan,Anusree Adukkadukkam,Kannan Meganathan^ORCID,Gopalan Natarajan,Vignesh Ramachandran,Murugesan Amudhan,Tan Hong Yien,Zhang Ying,Chandramathi Samudi,Sivasankaran Munusamy Ponnan^ORCID,Govindaraj Sakthivel,Byrareddy Siddappa N,Velu Vijayakumar,Larsson Marie^ORCID,Shankar Esaki M^ORCID,Raju Sivadoss

Abstract

ABSTRACTBackgroundEarly detection of latent tuberculosis infection (LTBI) is critical to TB elimination in the current WHO vision ofEnd Tuberculosis Strategy.MethodsWe investigated whether detecting plasma cytokines could aid in diagnosing LTBI across household contacts (HHCs) positive for IGRA, HHCs negative for IGRA, and healthy controls. We also measured the plasma cytokines using a commercialBio-Plex Pro Human Cytokine 17-plexassay.ResultsIncreased plasma CXCL8 and decreased MCP-1, TNF-α, and IFN-γ were associated with LTBI. Regression analysis showed that a combination of CXCL8 and MCP-1 increased the risk of LTBI among HHCs to 14-fold.ConclusionsWe postulated that CXCL8 and MCP-1 could be the surrogate biomarkers of LTBI, especially in resource-limited settings.

Publisher

Cold Spring Harbor Laboratory

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