Abstract
The incompleteness of race and ethnicity information in real-world data (RWD) hampers its utility in promoting healthcare equity. This study introduces two methods—one heuristic and the other machine learning-based—to impute race and ethnicity from continental genetic ancestry using tumor profiling data. Analyzing de-identified data from over 100,000 cancer patients sequenced with the Tempus xT panel, we demonstrate that both methods outperform existing geolocation and surname-based methods, with the machine learning approach achieving high recall (range: 0.783-0.997) and precision (range: 0.913-0.981) across four mutually exclusive race and ethnicity categories. This work presents a novel pathway to enhance RWD utility in studying racial disparities in healthcare.
Publisher
Cold Spring Harbor Laboratory
Reference27 articles.
1. Real-World Evidence: A Primer;Pharm. Med,2023
2. Medical Devices in the Real World;N. Engl. J. Med,2018
3. Studna, A. Executive Roundtable: The Rise of RWD in Clinical Research. Applied Clinical Trials https://www.appliedclinicaltrialsonline.com/view/executive-roundtable-the-rise-of-rwd-in-clinical-research (2023).
4. A framework for setting enrollment goals to ensure participant diversity in sponsored clinical trials in the United States;Contemp. Clin. Trials,2023
5. Mining for equitable health: Assessing the impact of missing data in electronic health records;J. Biomed. Inform,2023