Characterization of thyroid function in euthyroid and children with subclinical hypothyroidism using a multivariate homeostatic model

Abstract

AbstractBackgroundSubclinical hypothyroidism (SH) is biochemically defined by increased TSH, and normal thyroid hormones and its management is a matter of debate. Herein, we investigated thyroid function in euthyroid and children with SH using published data from population-based curves and a structure parameter inference approach (SPINA) model.MethodsThe study included 179 children and adolescents with SH and 311 healthy controls. The predicted and calculated secretory capacity of thyroid gland (SPINA-GT) was calculated in all euthyroid children divided into quartiles according to TSH values, and in children with SH, further subcategorized into those with mild SH (TSH: 4.5 – 10 mIU/L) and severe SH (TSH > 10 mIU/L).ResultsCalculated SPINA-GT values decreased significantly (P < 0.001) from the 1stto the 2ndquartile of normal TSH values in euthyroid children. It was also significantly decreased in mild SH compared to euthyroid children with TSH values within the upper 2 quartiles of TSH range and in severe SH compared to mild SH.ConclusionsThe implementation of SPINA model for thyroid function gives a wider perspective of thyroid gland’s performance within the euthyroid range of TSH, as well as in SH and add to the discussion for the long-term effects of SH and its management.