Author:
Alonso Mariana,Bekinschtein Pedro,Cammarota Martín,Vianna Monica R.M.,Izquierdo Iván,Medina Jorge H.
Abstract
Information storage in the brain is a temporally graded process involving
different memory phases as well as different structures in the mammalian
brain. Cortical plasticity seems to be essential to store stable long-term
memories, although little information is available at the moment regarding
molecular and cellular events supporting memory consolidation in the
neocortex. Brain-derived neurotrophic factor (BDNF) modulates both short-term
synaptic function and activity-dependent synaptic plasticity in hippocampal
and cortical neurons. We have recently demonstrated that endogenous BDNF in
the hippocampus is involved in memory formation. Here we examined the role of
BDNF in the parietal cortex (PCx) in short-term (STM) and long-term memory
(LTM) formation of a one-trial fear-motivated learning task in rats. Bilateral
infusions of function-blocking anti-BDNF antibody into the PCx impaired both
STM and LTM retention scores and decreased the phosphorylation state of cAMP
response element-binding protein (CREB). In contrast, intracortical
administration of recombinant human BDNF facilitated LTM and increased CREB
activation. Moreover, inhibitory avoidance training is associated with a rapid
and transient increase in phospho-CREB/total CREB ratio in the PCx. Thus, our
results indicate that endogenous BDNF is required for both STM and LTM
formation of inhibitory avoidance learning, possibly involving CREB
activation-dependent mechanisms. The present data support the idea that early
sensory areas constitute important components of the networks subserving
memory formation and that information processing in neocortex plays an
important role in memory formation.
Publisher
Cold Spring Harbor Laboratory
Subject
Cellular and Molecular Neuroscience,Cognitive Neuroscience,Neuropsychology and Physiological Psychology
Cited by
114 articles.
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