Author:
Sakamoto Yoshitaka,Xu Liu,Seki Masahide,Yokoyama Toshiyuki T.,Kasahara Masahiro,Kashima Yukie,Ohashi Akihiro,Shimada Yoko,Motoi Noriko,Tsuchihara Katsuya,Kobayashi Susumu,Kohno Takashi,Shiraishi Yuichi,Suzuki Ayako,Suzuki Yutaka
Abstract
AbstractHere we report identification of a new class of local structural aberrations in lung cancers. The whole-genome sequencing of cell lines using a long read sequencer, PromethION, demonstrated that typical cancerous mutations, such as point mutations, large deletions and gene fusions can be detected also on this platform. Unexpectedly, we revealed unique structural aberrations consisting of complex combinations of local duplications, inversions and micro deletions. We further analyzed and found that these mutations also occur in vivo, even in key cancer-related genes. These mutations may elucidate the molecular etiology of patients for whom causative cancerous events and therapeutic strategies remain elusive.
Publisher
Cold Spring Harbor Laboratory
Cited by
8 articles.
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