Abstract
SummaryThe high prevalence of post-acute sequelae of SARS-CoV-2 infection (PASC) is a significant health concern. In particular, virus-specific immunity in patients who suffer from chronic neurologic symptoms after acute SARS-CoV-2 infection remain poorly understood. Here, we report that Neuro-PASC patients have a specific immunological signature composed of humoral and cellular responses that are biased towards different SARS-CoV-2 structural proteins compared to healthy COVID convalescents, including a significant elevation in Nucleocapsid-specific antibody and T cell responses. Interestingly, the severity of cognitive deficits or quality of life markers in Neuro-PASC patients are associated with reduced effector molecule expression in memory T cells. Furthermore, we demonstrate a sustained elevation in T cell responses to SARS-CoV-2 mRNA vaccines in Neuro-PASC patients compared with healthy COVID convalescents. These data provide a framework for the rational design of predictive biomarkers and therapeutics for long COVID syndrome.
Publisher
Cold Spring Harbor Laboratory
Reference84 articles.
1. J. C. R. Center. (Johns Hopkins University of Medicine, Baltimore, MD, 2021), vol. 2021.
2. Gastrointestinal pathophysiology of SARS-CoV2 – a literature review
3. Subjective neurological symptoms frequently occur in patients with SARS-CoV2 infection
4. The neuroinvasive potential of SARS-CoV2 may play a role in the respiratory failure of COVID-19 patients;J Med Virol,2020
5. V. Higgins , D. Sohaei , E. P. Diamandis , I. Prassas , COVID-19: from an acute to chronic disease? Potential long-term health consequences. Crit Rev Clin Lab Sci, 1–23 (2020).
Cited by
40 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献