Abstract
AbstractAnalysis of the evolutionary conservation of amino acids is useful for the analysis of sequence variants detected in individuals with regard to possible impact on protein function. Rapid advances in DNA sequencing technologies are enabling affordable access to SNPs, exome sequencing, and whole genome shotgun sequencing. An understanding of the biological processes that have shaped diverging protein sequences aids the interpretation of sequence variants. The divergence model of protein evolution is presented as a general framework for interpreting information available from comparative analysis of protein sequences.
Publisher
Cold Spring Harbor Laboratory
Reference24 articles.
1. Darwin, C. , On the Origin of Species. 1859.
2. Evolutionary Rate at the Molecular Level
3. A method and server for predicting damaging missense mutations;Nat Meth,2010
4. Predicting Deleterious Amino Acid Substitutions
5. Zuckerkandl, E. and L. Pauling , Molecular disease, evolution, and genetic heterogeneity, in Horizons in Biochemistry, M. Kasha and B. Pullman , Editors. 1962, Academic Press, New York. p. 189-225.
Cited by
3 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献