Modeling Cerebral Hemodynamics Using BOLD Magnetic Resonance Imaging and its Application in Mild Cognitive Impairment

Abstract

AbstractObjectiveThis study develops a procedure and related analytical methods for deriving indices of cerebral hemodynamics in the magnetic resonance imaging (MRI) setting using resting state recordings of systemic blood pressure, pulse rate, and end-tidal CO2 synchronized with the MRI image acquisitions of blood oxygenation level dependent (BOLD) data as a measure of cerebral perfusion.MethodsWe employed the concept of Principal Dynamic Modes (PDM) to model the effect of three determinants of cerebral perfusion: mean arterial blood pressure (MABP), end-tidal CO2 (PETCO2), and pulse rate (PR). The relation between these signals and the BOLD signal were used respectively to quantify cerebral autoregulation (CA), CO2 vasoreactivity (CVR), and pulse rate reactivity (PRR).ResultsHemodynamic indices were obtained from 129 participants with normal cognition (NC) and mild cognitive impairment (MCI). CA was reduced in MCI compared to NC in the parietal lobe, CVR was reduced in MCI in the occipital and temporal lobes, and PRR was reduced in the frontal, parietal, occipital and temporal lobes. Reduced CVR and PRR were associated with worse cognitive scores including memory and executive function.ConclusionEmployed acquisition and analysis of MRI hemodynamic identified cerebral hemodynamic alterations in MCI, related to PR and ETCO2 changes.SignificanceThis modeling approach may offer a novel way to clinically assess cerebral hemodynamics during MRI.