Plasmon-Coupled Photocapacitor Neuromodulators

Author:

Melikov Rustamzhon,Srivastava Shashi Bhushan,Karatum Onuralp,Dogru Itir Bakis,Jalali Houman Bahmani,Sadeghi Sadra,Dikbas Ugur Meric,Ulgut Burak,Kavakli Ibrahim Halil,Nizamoglu Sedat

Abstract

AbstractEfficient transduction of optical energy to bioelectrical stimuli is an important goal for effective communication with biological systems. For that plasmonics has significant potential via boosting the light-matter interactions. However, plasmonics has been primarily used for heat-induced cell stimulation due to membrane capacitance change (i.e., optocapacitance). Instead, here we demonstrate that plasmonic coupling to photocapacitor biointerfaces improves safe and efficacious neuromodulating displacement charges for an average of 185% in the entire visible spectrum while maintaining the Faradaic currents below 1%. Hot-electron injection dominantly leads the enhancement of displacement current at blue spectral window, and nanoantenna effect is mainly responsible for the improvement at red-spectral region. The plasmonic photocapacitor facilitates wireless modulation of single cells at 3-orders of magnitude below the maximum retinal intensity levels corresponding to one of the most sensitive optoelectronic neural interfaces. This study introduces a new way of using plasmonics for safe and effective photostimulation of neurons and paves the way toward ultra-sensitive plasmon-assisted neurostimulation devices.

Publisher

Cold Spring Harbor Laboratory

Reference33 articles.

1. Five-Year Safety and Performance Results from the Argus II Retinal Prosthesis System Clinical Trial

2. Yuan, X. , A. Hierlemann , and U. Frey , Dual-mode microelectrode array with 20k-electrodes and high SNR for high-throughput extracellular recording and stimulation. Frontiers in Cellular Neuroscience, 2018. 12.

3. Extracellular excitation of central neurons: implications for the mechanisms of deep brain stimulation;Thalamus & Related Systems,2001

4. Novel interfaces for light directed neuronal stimulation: advances and challenges;International journal of nanomedicine,2014

5. Direct Electrical Neurostimulation with Organic Pigment Photocapacitors;Advanced Materials,2018

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3