Escargot is involved in labial and antennal imaginal disc development through two different developmental pathways

Abstract

AbstractIn insects, imaginal discs form the adult structures. Imaginal discs are formed by two epithelial layers, the lower disc proper columnar epithelium and the upper peripodial squamous epithelium (also known as peripodial membrane). During morphogenesis and metamorphosis there is a complex crosstalk between these two epithelia that defines the final size and form of the adult organs. In this work we found that in the antennal disc, the dosage of the transcriptional factor Escargot (Esg) regulates the extension of the peripodial epithelium. A reduction in Esg expands the peripodial domain at the expense of the antennal disc proper causing a distortion of the anteroposterior compartments resulting in malformations or duplications of antennae and maxillary palps. In the labial disc, a different morphogenetic pathway controls its development, and loss of esg produces a complete loss of the proboscis through a pathway that involves dpp.Summary statementThe gene escargot regulates proboscis, maxillary palps and antennae development in Drosophila melanogaster through two different developmental pathways: one involving cell adhesion protein DE-cadherin and another through the signaling molecule decapentaplegic.